Control of apoptosis by p53

Fridman, J. S., Lowe, S. W. (December 2003) Control of apoptosis by p53. Oncogene, 22 (56). pp. 9030-9040. ISSN 0950-9232

URL: http://www.ncbi.nlm.nih.gov/pubmed/14663481
DOI: 10.1038/sj.onc.1207116

Abstract

The p53 tumor suppressor acts to integrate multiple stress signals into a series of diverse antiproliferative responses. One of the most important p53 functions is its ability to activate apoptosis, and disruption of this process can promote tumor progression and chemoresistance. p53 apparently promotes apoptosis through transcription-dependent and -independent mechanisms that act in concert to ensure that the cell death program proceeds efficiently. Moreover, the apoptotic activity of p53 is tightly controlled, and is influenced by a series of quantitative and qualitative events that influence the outcome of p53 activation. Interestingly, other p53 family members can also promote apoptosis, either in parallel or in concert with p53. Although incomplete, our current understanding of p53 illustrates how apoptosis can be integrated into a larger tumor suppressor network controlled by different signals, environmental factors, and cell type. Understanding this network in more detail will provide insights into cancer and other diseases, and will identify strategies to improve their therapeutic treatment.

Item Type: Paper
Uncontrolled Keywords: P73 P53 P63 apoptosis tumor suppressor WILD-TYPE P53 TUMOR-SUPPRESSOR P53 CELL-CYCLE ARREST DNA-DAMAGE P53-DEPENDENT APOPTOSIS TRANSCRIPTIONAL ACTIVATION IN-VIVO MEDIATED APOPTOSIS HUMAN CANCER P53-INDUCED APOPTOSIS
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
organs, tissues, organelles, cell types and functions > cell types and functions
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p53
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p63
CSHL Authors:
Communities: CSHL labs > Lowe lab
Depositing User: Matt Covey
Date: December 2003
Date Deposited: 27 Mar 2013 15:39
Last Modified: 27 Mar 2013 15:39
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28016

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