Aging specifically impairs amnesiac-dependent memory in Drosophila

Tamura, T., Chiang, A. S., Ito, N., Liu, H. P., Horiuchi, J., Tully, T., Saitoe, M. (December 2003) Aging specifically impairs amnesiac-dependent memory in Drosophila. Neuron, 40 (5). pp. 1003-1011. ISSN 0896-6273

URL: http://www.ncbi.nlm.nih.gov/pubmed/14659098
DOI: 10.1016/S0896-6273(03)00732-3

Abstract

Age-related memory impairment (AMI) is observed in many species. However, it is uncertain whether AMI results from a specific or a nonspecific decay in memory processing. In Drosophila, memory acquired after a single olfactory conditioning paradigm has three distinct phases: short-term memory (STM), middle-term memory (MTM), and longer-lasting anesthesia-resistant memory (ARM). Here, we demonstrate that age-related defects in olfactory memory are identical to those of the MTM mutant amnesiac (amn). Furthermore, amn flies do not exhibit an age-dependent decrease in memory, in contrast to other memory mutants. The absence of AMI in amn flies is restored by expression of an amn transgene predominantly in DPM cells. Thus, we propose that AMI in flies results from a specific decrease in amn-dependent MTM.

Item Type: Paper
Uncontrolled Keywords: CAMP SIGNALING PATHWAY LONG-TERM POTENTIATION MUSHROOM BODIES CONSOLIDATED MEMORY MUTANT DROSOPHILA OLFACTORY MEMORY IMPROVES MEMORY GENE-PRODUCT AGE MELANOGASTER
Subjects: organism description > animal > insect > Drosophila
organism description > animal behavior > memory
organs, tissues, organelles, cell types and functions > tissues types and functions > mushroom body
organs, tissues, organelles, cell types and functions
organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:
Communities: CSHL labs > Tully lab
Depositing User: Matt Covey
Date: December 2003
Date Deposited: 01 Apr 2013 19:22
Last Modified: 01 Apr 2013 19:22
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28015

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