Maintenance of heterochromatin by RNA interference of tandem repeats

Martienssen, R. A. (2003) Maintenance of heterochromatin by RNA interference of tandem repeats. Nature Genetics, 35 (3). pp. 213-4. ISSN 1061-4036

URL: http://www.ncbi.nlm.nih.gov/pubmed/14593407
DOI: 10.1038/ng1252

Abstract

Tandem repeats are prone to epigenetic silencing regulated by RNA interference. This may be because siRNAs from tandem array transcripts are regenerated by RNA-dependent RNA polymerase (RdRP) and Dicer, but siRNAs from single-copy sequences are exhausted by sequential use of downstream primers by RdRP. This could account for the formation of heterochromatin from tandem repeats.

Item Type: Paper
Uncontrolled Keywords: Heterochromatin genetics RNA Interference Tandem Repeat Sequences
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > Chromatin dynamics
CSHL Authors:
Communities: CSHL labs > Martienssen lab
Depositing User: Matt Covey
Date Deposited: 28 Mar 2013 13:48
Last Modified: 28 Mar 2013 13:48
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28003

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving