Plasticity of calcium channels in dendritic spines

Yasuda, R., Sabatini, B. L., Svoboda, K. (September 2003) Plasticity of calcium channels in dendritic spines. Nature Neuroscience, 6 (9). pp. 948-55. ISSN 1097-6256

URL: http://www.ncbi.nlm.nih.gov/pubmed/12937422
DOI: 10.1038/nn1112

Abstract

Voltage-sensitive Ca2+ channels (VSCCs) constitute a major source of calcium ions in dendritic spines, but their function is unknown. Here we show that R-type VSCCs in spines of rat CA1 pyramidal neurons are depressed for at least 30 min after brief trains of back-propagating action potentials. Populations of channels in single spines are depressed stochastically and synchronously, independent of channels in the parent dendrite and other spines, implying that depression is the result of signaling restricted to individual spines. Induction of VSCC depression blocks theta-burst-induced long-term potentiation (LTP), indicating that postsynaptic action potentials can modulate synaptic plasticity by tuning VSCCs. Induction of depression requires [Ca2+] elevations and activation of L-type VSCCs, which activate Ca2+/calmodulin-dependent kinase II (CaMKII) and a cyclic adenosine monophosphate (cAMP)-dependent pathway. Given that L-type VSCCs do not contribute measurably to Ca2+ influx in spines, they must activate downstream effectors either directly through voltage-dependent conformational changes or via [Ca2+] microdomains.

Item Type: Paper
Uncontrolled Keywords: Action Potentials/drug effects/ physiology Animals Calcium/pharmacology/physiology Calcium Channels, R-Type/ physiology Dendrites/drug effects/ physiology Hippocampus/cytology/drug effects/physiology Neuronal Plasticity/drug effects/ physiology Rats
Subjects: organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > calcium channel
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions > cell types

organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic spines
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic spines
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic spines

organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions
CSHL Authors:
Communities: CSHL labs > Svoboda lab
Depositing User: Matt Covey
Date: September 2003
Date Deposited: 10 Jun 2013 20:04
Last Modified: 10 Jun 2013 20:04
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27978

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