Control of axon branch dynamics by correlated activity in vivo

Ruthazer, E. S., Akerman, C. J., Cline, H. T. (July 2003) Control of axon branch dynamics by correlated activity in vivo. Science, 301 (5629). pp. 66-70. ISSN 0036-8075

URL: http://www.ncbi.nlm.nih.gov/pubmed/12843386
DOI: 10.1126/science.1082545

Abstract

To determine how patterned visual activity regulates the development of axonal projections, we collected in vivo time-lapse images of retinal axons from albino Xenopus tadpoles in which binocular innervation of the optic tectum was induced. Axons added branch tips with nearly equal probability in all territories, but eliminated them preferentially from territory dominated by the opposite eye. This selective branch elimination was abolished by blockade of N-methyl-D-aspartate receptors. These results describe a correlation-based mechanism by which visual experience directly governs axon branch dynamics that contribute to the development of topographic maps.

Item Type: Paper
Uncontrolled Keywords: RECEPTOR ANTAGONISTS DISRUPT NMDA RECEPTOR VISUAL-CORTEX SYNAPSE ELIMINATION RETINOTECTAL AXONS RANA-PIPIENS TIME-LAPSE PROJECTION MAP ZEBRAFISH
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > axon
organs, tissues, organelles, cell types and functions > tissues types and functions
organism description > animal behavior > vision
organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex
CSHL Authors:
Communities: CSHL labs > Cline lab
Depositing User: Matt Covey
Date: July 2003
Date Deposited: 11 Jun 2013 15:46
Last Modified: 11 Jun 2013 15:46
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27951

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