A pivotal role of the coiled coil of Sir4

Xu, R. M. (June 2003) A pivotal role of the coiled coil of Sir4. Structure, 11 (6). pp. 608-609. ISSN 0969-2126

URL: http://www.ncbi.nlm.nih.gov/pubmed/12791247
DOI: 10.1016/S0969-2126(03)00102-3

Abstract

The C terminus of Sir4 forms a coiled-coil structure. The coiled-coil domain is responsible for the dimerization of Sir4 and contains the binding site of Sir3. Structural and biochemical analyses of the Sir4 coiled-coil domain provide important insights into the molecular mechanisms of Sir3-Sir4 interaction and the assembly of a ternary Sir2/Sir3/Sir4 complex that are essential for epigenetic control of gene expression in S. cerevisiae.

Item Type: Paper
Uncontrolled Keywords: SACCHAROMYCES-CEREVISIAE TELOMERIC HETEROCHROMATIN SIR2/SIR4 COMPLEX YEAST BINDING
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
organism description > yeast
CSHL Authors:
Communities: CSHL labs > Xu lab
Depositing User: Matt Covey
Date: June 2003
Date Deposited: 11 Jun 2013 20:15
Last Modified: 11 Jun 2013 20:15
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27936

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving