Apoptosis and melanoma chemoresistance

Soengas, M. S., Lowe, S. W. (May 2003) Apoptosis and melanoma chemoresistance. Oncogene, 22 (20). pp. 3138-3151. ISSN 0950-9232

URL: http://www.ncbi.nlm.nih.gov/pubmed/12789290
DOI: 10.1038/sj.onc.1206454

Abstract

Melanoma is the most aggressive form of skin cancer and is notoriously resistant to all current modalities of cancer therapy. A large set of genetic, functional and biochemical studies suggest that melanoma cells become 'bullet proof' against a variety of chemotherapeutic drugs by exploiting their intrinsic resistance to apoptosis and by reprogramming their proliferation and survival pathways during melanoma progression. In recent years, the identification of molecules involved in the regulation and execution of apoptosis, and their alteration in melanoma, have provided new insights into the molecular basis for melanoma chemoresistance. With this knowledge in hand, the challenge is now to devise strategies potent enough to compensate or bypass these cell death defects and improve the actual poor prognosis of patients at late stages of the disease.

Item Type: Paper
Uncontrolled Keywords: skin cancer drug resistance apoptosis cancer therapy chemotherapeutic targets NF-KAPPA-B HUMAN METASTATIC MELANOMA PROGRAMMED CELL-DEATH CYTOCHROME-C RELEASE WILD-TYPE P53 DIFFERENTIATION-ASSOCIATED GENE-7 SMALL-MOLECULE INHIBITORS PROTEIN-KINASE-B MALIGNANT-MELANOMA IN-VIVO
Subjects: diseases & disorders > cancer
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
organs, tissues, organelles, cell types and functions > cell types and functions
diseases & disorders > cancer > drugs and therapies > chemoresistance
diseases & disorders > cancer > drugs and therapies
diseases & disorders > cancer > cancer types > melanomas
diseases & disorders > cancer > cancer types
CSHL Authors:
Communities: CSHL labs > Lowe lab
Depositing User: Matt Covey
Date: May 2003
Date Deposited: 11 Jun 2013 20:09
Last Modified: 11 Jun 2013 20:09
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27935

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