Skp2 regulates Myc protein stability and activity

Kim, S. Y., Herbst, A., Tworkowski, K. A., Salghetti, S. E., Tansey, W. P. (May 2003) Skp2 regulates Myc protein stability and activity. Molecular Cell, 11 (5). pp. 1177-1188. ISSN 1097-2765

URL: http://www.ncbi.nlm.nih.gov/pubmed/12769843
DOI: 10.1016/S1097-2765(03)00173-4

Abstract

Myc is an oncoprotein transcription factor that plays a prominent role in cancer. Like many transcription factors, Myc is an unstable protein that is destroyed by ubiquitin (Ub)-mediated proteolysis. Here, we report that the oncoprotein and Ub ligase Skp2 regulates Myc ubiquitylation and stability. Because of the growing number of Ub ligases that function as transcriptional coactivators, we speculated that Skp2 might also regulate Myc's transcriptional activity. Consistent with this model, we also show that Skp2 is a transcriptional coactivator for Myc, recognizing an essential element within the Myc activation domain and activating Myc target genes. These data suggest that Skp2 functions to connect Myc activity and destruction, and reveal an unexpected oncoprotein connection that may play an important role in controlling cell growth in normal and cancer cells.

Item Type: Paper
Uncontrolled Keywords: UBIQUITIN-MEDIATED PROTEOLYSIS ACTIVATION-DOMAIN FUNCTION C-MYC IN-VIVO CELL-CYCLE F-BOX TRANSCRIPTIONAL REGULATION HETEROLOGOUS PROTEINS BURKITTS-LYMPHOMA RESPONSIVE GENES
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > Myc
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types
CSHL Authors:
Communities: CSHL labs > Tansey lab
Depositing User: Matt Covey
Date: May 2003
Date Deposited: 27 Jun 2013 14:47
Last Modified: 27 Jun 2013 14:47
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27931

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