The making of the mitotic chromosome: Modern insights into classical questions

Swedlow, J. R., Hirano, T. (March 2003) The making of the mitotic chromosome: Modern insights into classical questions. Molecular Cell, 11 (3). pp. 557-569. ISSN 1097-2765

URL: http://www.ncbi.nlm.nih.gov/pubmed/12667441
DOI: 10.1016/S1097-2765(03)00103-5

Abstract

The condensation of mitotic chromosomes is essential for the faithful segregation of sister chromatids in anaphase. An emerging view is that chromosome assembly is an active and dynamic process of chromatin reorganization in which two ATP hydrolyzing enzymes, topoisomerase II and the condensin complex, play central roles. In this review, we discuss recent work that sheds new light on the molecular and structural dynamics of mitotic chromosomes.

Item Type: Paper
Uncontrolled Keywords: DNA TOPOISOMERASE-II HISTONE H3 PHOSPHORYLATION CHROMATIN REMODELING COMPLEX XENOPUS EGG EXTRACTS NON-SMC SUBUNITS AURORA-B KINASE METAPHASE CHROMOSOME CONDENSIN COMPLEX SISTER CHROMATIDS 13S CONDENSIN
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > histone
organs, tissues, organelles, cell types and functions > organelles, types and functions > mitosis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL labs > Hirano lab
Depositing User: Matt Covey
Date: March 2003
Date Deposited: 27 Jun 2013 15:34
Last Modified: 27 Jun 2013 15:34
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27904

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