How the ubiquitin-proteasome system controls transcription

Muratani, Masafumi, Tansey, William P. (March 2003) How the ubiquitin-proteasome system controls transcription. Nature Reviews Molecular Cell Biology, 4 (3). pp. 192-201. ISSN 1471-0072

URL: http://www.ncbi.nlm.nih.gov/pubmed/12612638
DOI: 10.1038/nrm1049

Abstract

Gene transcription and ubiquitin-mediated proteolysis are two processes that have seemingly nothing in common: transcription is the first step in the life of any protein and proteolysis the last. Despite the disparate nature of these processes, a growing body of evidence indicates that ubiquitin and the proteasome are intimately involved in gene control. Here, we discuss the deep mechanistic connections between transcription and the ubiquitin-proteasome system, and highlight how the intersection of these processes tightly controls expression of the genetic information.

Item Type: Paper
Uncontrolled Keywords: RNA-POLYMERASE-II TATA-BINDING PROTEIN SACCHAROMYCES-CEREVISIAE 26S PROTEASOME HISTONE H2B MEDIATED DEGRADATION ACTIVATION DOMAIN LARGE SUBUNIT DNA-DAMAGE DEPENDENT DEGRADATION
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > DNA polymerase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > proteolysis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > ubiquitin ligase
CSHL Authors:
Communities: CSHL labs > Tansey lab
Watson School > Publications
Depositing User: Matt Covey
Date: March 2003
Date Deposited: 01 Jul 2013 16:45
Last Modified: 19 Sep 2014 14:43
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27894

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