Hippocampal place cells acquire location-specific responses to the conditioned stimulus during auditory fear conditioning

Moita, M. A. P., Rosis, S., Zhou, Y., LeDoux, J. E., Blair, H. T. (February 2003) Hippocampal place cells acquire location-specific responses to the conditioned stimulus during auditory fear conditioning. Neuron, 37 (3). pp. 485-497. ISSN 0896-6273

URL: http://www.ncbi.nlm.nih.gov/pubmed/12575955
DOI: 10.1016/S0896-6273(03)00033-3

Abstract

We recorded neurons from the hippocampus of freely behaving rats during an auditory fear conditioning task. Rats received either paired or unpaired presentations of an auditory conditioned stimulus (CS) and an electric shock unconditioned stimulus (US). Hippocampal neurons (place and theta cells) acquired responses to the auditory CS in the paired but not in the unpaired group. After CS-US pairing, rhythmic firing of theta cells became synchronized to the onset of the CS. Conditioned responses of place cells were gated by their location-specific firing, so that after CS-US pairing, place cells responded to the CS only when the rat was within the cell's place field. These findings may help to elucidate how the hippocampus contributes to context-specific memory formation during associative learning.

Item Type: Paper
Uncontrolled Keywords: LATERAL AMYGDALA NEURONS LONG-TERM POTENTIATION COMPLEX-SPIKE CELLS CONTEXTUAL FEAR RECOGNITION MEMORY UNIT-ACTIVITY RETROGRADE-AMNESIA THETA-CELLS RAT BEHAVIOR
Subjects: organism description > animal behavior
organism description > animal behavior > fear
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:
Communities: CSHL labs > Zador lab
Depositing User: Matt Covey
Date: February 2003
Date Deposited: 01 Jul 2013 20:20
Last Modified: 01 Jul 2013 20:20
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27883

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