Lowe, S. W., Sherr, C. J. (February 2003) Tumor suppression by Ink4a-Arf: progress and puzzles. Current Opinion in Genetics & Development, 13 (1). pp. 77-83. ISSN 0959-437X
Abstract
The two products of the Ink4a-Arf locus, p16(Ink4a) and p19(Arf) (p14(ARF) in humans), are potent tumor suppressors that regulate the activities of the retinoblastoma protein and the p53 transcription factor. These proteins form part of a signaling network that is disrupted in most, if not all, cancer cells. The Ink4a-Arf locus responds to stress signals, limiting cell proliferation and modulating oncogene-induced apoptosis. Recent evidence emerging from mouse tumor models distinguishes the activities of p16(Ink4a) and p19(Arf) in regulating tumor onset and identifies differences in their responsiveness to drugs.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | TRANSCRIPTIONAL ACTIVATION REPLICATIVE SENESCENCE P16(INK4A) EXPRESSION CELLULAR SENESCENCE ONCOGENIC RAS G(1) CONTROL P19(ARF) PATHWAY CELLS P53 |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types |
| CSHL Authors: | |
| Communities: | CSHL labs > Lowe lab |
| Depositing User: | Matt Covey |
| Date: | February 2003 |
| Date Deposited: | 01 Jul 2013 20:17 |
| Last Modified: | 01 Jul 2013 20:17 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27881 |
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