Tumor suppression by Ink4a-Arf: progress and puzzles

Lowe, S. W., Sherr, C. J. (February 2003) Tumor suppression by Ink4a-Arf: progress and puzzles. Current Opinion in Genetics & Development, 13 (1). pp. 77-83. ISSN 0959-437X

URL: http://www.ncbi.nlm.nih.gov/pubmed/12573439
DOI: 10.1016/S0959-437X(02)00013-8

Abstract

The two products of the Ink4a-Arf locus, p16(Ink4a) and p19(Arf) (p14(ARF) in humans), are potent tumor suppressors that regulate the activities of the retinoblastoma protein and the p53 transcription factor. These proteins form part of a signaling network that is disrupted in most, if not all, cancer cells. The Ink4a-Arf locus responds to stress signals, limiting cell proliferation and modulating oncogene-induced apoptosis. Recent evidence emerging from mouse tumor models distinguishes the activities of p16(Ink4a) and p19(Arf) in regulating tumor onset and identifies differences in their responsiveness to drugs.

Item Type: Paper
Uncontrolled Keywords: TRANSCRIPTIONAL ACTIVATION REPLICATIVE SENESCENCE P16(INK4A) EXPRESSION CELLULAR SENESCENCE ONCOGENIC RAS G(1) CONTROL P19(ARF) PATHWAY CELLS P53
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL labs > Lowe lab
Depositing User: Matt Covey
Date: February 2003
Date Deposited: 01 Jul 2013 20:17
Last Modified: 01 Jul 2013 20:17
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27881

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