PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity

Esteban, J. A., Shi, S. H., Wilson, C., Nuriya, M., Huganir, R. L., Malinow, R. (February 2003) PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity. Nature Neuroscience, 6 (2). pp. 136-143. ISSN 1097-6256

URL: http://www.ncbi.nlm.nih.gov/pubmed/12536214
DOI: 10.1038/nn997

Abstract

The regulated incorporation of AMPA receptors into synapses is important for synaptic plasticity. Here we examine the role of protein kinase A (PKA) in this process. We found that PKA phosphorylation of the AMPA receptor subunits GluR4 and GluR1 directly controlled the synaptic incorporation of AMPA receptors in organotypic slices from rat hippocampus. Activity-driven PKA phosphorylation of GluR4 was necessary and sufficient to relieve a retention interaction and drive receptors into synapses. In contrast, PKA phosphorylation of GluR1 and the activity of calcium/calmodulin-dependent kinase II (CaMKII) were both necessary for receptor incorporation. Thus, PKA phosphorylation of AMPA receptor subunits contributes to diverse mechanisms underlying synaptic plasticity.

Item Type: Paper
Uncontrolled Keywords: LONG-TERM POTENTIATION DEPENDENT PROTEIN-KINASE CYCLIC-AMP FREQUENCY STIMULATION ACTIVATION INCREASES HIPPOCAMPAL SYNAPSES GLUTAMATE RECEPTORS LATE-PHASE AREA CA1 LTP
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > AMPA receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression > phosphorylation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic transmission
CSHL Authors:
Communities: CSHL labs > Malinow lab
Depositing User: Matt Covey
Date: February 2003
Date Deposited: 01 Jul 2013 19:28
Last Modified: 01 Jul 2013 19:28
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27874

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