Postnatal development of GABAergic signalling in the rat lateral geniculate nucleus: presynaptic dendritic mechanisms

Perreault, M. C., Qin, Y., Heggelund, P., Zhu, J. J. (2003) Postnatal development of GABAergic signalling in the rat lateral geniculate nucleus: presynaptic dendritic mechanisms. Journal of Physiology-London, 546 (1). pp. 137-148. ISSN 0022-3751

URL: http://www.ncbi.nlm.nih.gov/pubmed/12509484
DOI: 10.1113/jphysiol.2002.030643

Abstract

Diverse forms of GABAergic inhibition are found in the mature brain. To understand how this diversity develops, we studied the changes in morphology of inhibitory interneurons and changes in interneuron-mediated synaptic transmission in the rat dorsal lateral geniculate nucleus (dLGN). We found a steady expansion of the dendritic tree of interneurons over the first three postnatal weeks. During this period, the area around a thalamocortical cell from which GABA(A) inhibition could be elicited also expanded. Dendritic branching and burst firing in interneurons evolved more slowly. The distal dendrites of interneurons began to branch extensively after the third week, and at the same time burst firing appeared. The appearance of burst firing and an elaborated dendritic tree were accompanied by a pronounced GABA(B) inhibition of thalamocortical cells. Thus, GABA inhibition of thalamocortical. cells developed from one type of GABAA inhibition (spatially restricted) in the young animal into two distinct types of GABAA inhibition (short- and long-range) and GABAB inhibition in the adult animal. The close temporal relationships between the development of the diverse forms of inhibition and the postnatal changes in morphology of local GABAergic interneurons in the dLGN suggest that postnatal dendritic maturation is an important presynaptic factor for the developmental time course of the various types of feed forward inhibition in thalamus.

Item Type: Paper
Uncontrolled Keywords: INHIBITORY POSTSYNAPTIC POTENTIALS BRAIN-STEM MODULATION NEOCORTICAL PYRAMIDAL NEURONS PRIMARY SOMATOSENSORY CORTEX RECEPTIVE-FIELD PROPERTIES GAMMA-AMINOBUTYRIC-ACID SILENT SYNAPSES THALAMIC INTERNEURONS AMPA RECEPTORS BARREL CORTEX
Subjects: bioinformatics > genomics and proteomics > small molecules > GABA
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells

bioinformatics > genomics and proteomics > small molecules
CSHL Authors:
Communities: CSHL labs > Malinow lab
CSHL labs > Van Aelst lab
Depositing User: Matt Covey
Date Deposited: 01 Jul 2013 21:08
Last Modified: 01 Jul 2013 21:08
PMCID: PMC2342475
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27867

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving