Stretching of macromolecules and proteins

Strick, T. R., Dessinges, M. N., Charvin, G., Dekker, N. H., Allemand, J. F., Bensimon, D., Croquette, V. (January 2003) Stretching of macromolecules and proteins. Reports on Progress in Physics, 66 (1). pp. 1-45. ISSN 0034-4885

URL: http://iopscience.iop.org/0034-4885/66/1/201
DOI: 10.1088/0034-4885/66/1/201

Abstract

In this paper we review the biophysics revealed by stretching single biopolymers. During the last decade various techniques have emerged allowing micromanipulation of single molecules and simultaneous measurements of their elasticity. Using such techniques, it has been possible to investigate some of the interactions playing a role in biology. We shall first review the simplest case of a non-interacting polymer and then present the structural transitions in DNA, RNA and proteins that have been studied by single-molecule techniques. We shall explain how these techniques permit a new approach to the protein folding/unfolding transition.

Item Type: Paper
Uncontrolled Keywords: ATOMIC-FORCE MICROSCOPY DOUBLE-STRANDED DNA SUPERCOILED DNA SINGLE-MOLECULE DOUBLE HELIX CONFORMATIONAL FLUCTUATIONS STRUCTURAL TRANSITIONS COMPLEMENTARY STRANDS ENTROPIC ELASTICITY PICONEWTON FORCES
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
CSHL Authors:
Communities: CSHL labs > Strick lab
Depositing User: Matt Covey
Date: January 2003
Date Deposited: 08 Jul 2013 20:49
Last Modified: 08 Jul 2013 20:49
URI: http://repository.cshl.edu/id/eprint/27846

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