New functions for the matrix metalloproteinases in cancer progression

Egeblad, M., Werb, Z. (2002) New functions for the matrix metalloproteinases in cancer progression. Nature Reviews Cancer, 2 (3). pp. 161-174. ISSN 1474175X (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/11990853
DOI: 10.1038/nrc745

Abstract

Matrix metalloproteinases (MMPs) have long been associated with cancer-cell invasion and metastasis. This provided the rationale for clinical trials of MMP inhibitors, unfortunately with disappointing results. We now know, however, that the MMPs have functions other than promotion of invasion, have substrates other than components of the extracellular matrix, and that they function before invasion in the development of cancer. With this knowledge in hand, can we rethink the use of MMP inhibitors in the clinic?

Item Type: Paper
Uncontrolled Keywords: matrix metalloproteinase ae 941 batimastat cgs 27023a collagenase 3 gelatinase A gelatinase B interstitial collagenase macrophage elastase marimastat matrilysin matrix metalloproteinase 14 matrix metalloproteinase 15 matrix metalloproteinase 16 matrix metalloproteinase 17 matrix metalloproteinase 18 matrix metalloproteinase 19 matrix metalloproteinase 20 matrix metalloproteinase 21 matrix metalloproteinase 22 matrix metalloproteinase inhibitor mm 1270 neutrophil collagenase prinomastat rebimastat stromelysin stromelysin 2 stromelysin 3 tanomastat tissue inhibitor of metalloproteinase unclassified drug unindexed drug cell transformation disease course enzymology human metabolism neoplasm pathology pathophysiology review cancer growth cancer invasion cell invasion clinical research disease association enzyme assay enzyme mechanism enzyme substrate extracellular matrix metastasis nucleotide sequence priority journal Cell Transformation, Neoplastic Disease Progression Humans Matrix Metalloproteinases Neoplasms
Subjects: diseases & disorders > cancer
diseases & disorders
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > metalloproteinases
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL labs > Egeblad lab
Depositing User: Matt Covey
Date: 2002
Date Deposited: 14 Mar 2013 19:46
Last Modified: 14 Mar 2013 19:46
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27814

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