Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p

Nishijima, I., Mills, A., Qi, Y., Mills, M., Bradley, A. (July 2003) Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis, 36 (3). pp. 142-148. ISSN 1526-954X

URL: http://www.ncbi.nlm.nih.gov/pubmed/12872245
DOI: 10.1002/gene.10207

Abstract

To facilitate genetic screens to identify and maintain recessive mutations that map to the short arm of human chromosome 1, we have utilized chromosome engineering to generate two mouse strains that carry large inversions on the distal region of mouse chromosome 4. The inversion intervals are 16 and 22 cM in size together they cover approximately half of chromosome 4. Since recombination between the wild-type and inversion chromosomes does not occur within these inversion intervals, mutant alleles of genes mapping to this region can be identified and maintained. Therefore, these inversion chromosomes work as balancer chromosomes. These inversions have the additional advantage that they are tagged with genes encoding the visible coat color markers tyrosinase and agouti, and therefore the dosage of the inversion chromosome (+/+, Inv/+, Inv/Inv) can be visually recognized. These inversion strains will be extremely useful for mutagenesis screens that focus on functional annotation of human chromosome 1p. genesis 36:142-148, 2003. (C) 2003 Wiley-Liss, Inc.

Item Type: Paper
Uncontrolled Keywords: mouse chromosome 4 inversion balancer chromosomes coat color marker BAND 1P36 MOUSE DELETION REGION TUMORIGENESIS MUTAGENESIS DISEASE MICE MAP
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function
organism description > animal > mammal > primates > hominids > human
organism description > animal > mammal > rodent > mouse
CSHL Authors:
Communities: CSHL labs > Mills lab
Depositing User: Matt Covey
Date: July 2003
Date Deposited: 11 Mar 2013 19:55
Last Modified: 11 Mar 2013 19:55
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27768

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