p63 is a p53 homologue required for limb and epidermal morphogenesis

Mills, A. A., Zheng, B., Wang, X. J., Vogel, H., Roop, D. R., Bradley, A. (1999) p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature, 398 (6729). pp. 708-713. ISSN 00280836 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/10227293
DOI: 10.1038/19531

Abstract

The p53 tumour suppressor is a transcription factor that regulates the progression of the cell through its cycle and cell death (apoptosis) in response to environmental stimuli such as DNA damage and hypoxia. Even though p53 modulates these critical cellular processes, mice that lack p53 are developmentally normal, suggesting that p53-related proteins might compensate for the functions of p53 during embryogenesis. Two p53 homologues, p63 and p73, are known and here we describe the function of p63 in vivo. Mice lacking p63 are born alive but have striking developmental defects. Their limbs are absent or truncated, defects that are caused by a failure of the apical ectodermal ridge to differentiate. The skin of p63-deficient mice does not progress past an early developmental stage: it lacks stratification and does not express differentiation markers. Structures dependent upon epidermal- mesenchymal interactions during embryonic development, such as hair follicles, teeth and mammary glands, are absent in p63-deficient mice. Thus, in contrast to p53, p63 is essential for several aspects of ectodermal differentiation during embryogenesis.

Item Type: Paper
Uncontrolled Keywords: protein derivative protein p53 protein p63 unclassified drug animal experiment animal tissue article embryo development epidermis cell gene expression limb development morphogenesis mouse nonhuman pathological anatomy priority journal protein analysis sequence homology Animals Body Patterning Epidermis Female Forelimb Gene Expression Regulation, Developmental Gene Transfer Techniques Genes, p53 Hindlimb Limb Bud Limb Deformities, Congenital Male Membrane Proteins Mice Mice, Inbred C57BL Phosphoproteins Trans-Activators
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p53
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p63
CSHL Authors:
Communities: CSHL labs > Mills lab
Depositing User: Matt Covey
Date: 1999
Date Deposited: 11 Mar 2013 20:27
Last Modified: 11 Mar 2013 20:27
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27761

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving