Replication of DNA in adenovirus-infected cells

Stillman, B. W., Bellett, A. J. D. (1979) Replication of DNA in adenovirus-infected cells. Cold Spring Harbor Symposia on Quantitative Biology, 43 (2). pp. 729-739. ISSN 00917451 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/226317
DOI: 10.1101/SQB.1979.043.01.081

Abstract

Cells abortively infected with oncogenic adenovirus (Ad) show evidence of abnormal cellular DNA replication (Strohl 1973), and Ad mutants that are temperature-sensitive for viral DNA replication have altered abilities to transform the host cell (Williams et al. 1975). These effects are most probably a result of the expression of early viral proteins, which are necessary for viral DNA replication and which, in transformed cells, cause cellular DNA replication under conditions that restrict normal cells. Thus, in order to understand the process of Ad-induced cell transformation, it is necessary to understand the mechanism of initiation of viral DNA replication and the proteins involved in that process, and also the effect of viral infection on cellular DNA replication. Consequently, we have studied the replication of Ad DNA during productive infection and viral and cellular DNA synthesis during nonproductive infection. Ad DNA, isolated from the virion, exists as a linear double-stranded chromosome with...

Item Type: Paper
Uncontrolled Keywords: virus dna animal experiment cell culture human cell in vitro study mastadenovirus virus infection Adenoviruses, Human Animal Cell Cycle Cell Transformation, Viral Cells, Cultured Deoxyribonucleoproteins DNA DNA Helicases DNA Replication DNA, Single-Stranded DNA, Viral Human Mice Viral Proteins Virus Replication
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
organism description > virus > adeno associated virus
organism description > virus
CSHL Authors:
Communities: CSHL labs > Stillman lab
Highlight: Stillman, Bruce W.
Depositing User: Matt Covey
Date Deposited: 08 Mar 2013 18:41
Last Modified: 20 Jun 2017 20:48
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27729

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