Basic pathophysiological mechanisms in depression: what are they and how might they affect the course of the illness?

Henn, F. A., Vollmayr, B. (November 2004) Basic pathophysiological mechanisms in depression: what are they and how might they affect the course of the illness? Pharmacopsychiatry, 37 Sup. S152-6. ISSN 0176-3679 (Print)0176-3679 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/15546068
DOI: 10.1055/s-2004-832670

Abstract

Basic pathophysiological mechanisms in affective disorders are discussed. Studies carried out suggest that changes in neurogenesis do not underlie the behavioral changes which lead to helplessness. Since the behavioral changes leading to depressive or anxious behaviors are not correlated with changes in neurogenesis it appears unlikely that a decrease in the rate of neurogenesis is the basis for depression. A modified gene expression resulting in both functional and structural brain changes remains the most consistent hypothesis to explain how affective disorders may occur. An alternative candidate, synaptogenesis, appears as a likely candidate and requires further experimental testing.

Item Type: Paper
Uncontrolled Keywords: Brain/pathology/ physiopathology Depression/pathology/ physiopathology Humans Hypothalamo-Hypophyseal System/physiopathology Nerve Net/pathology/ physiopathology Neurotransmitter Agents/physiology Pituitary-Adrenal System/physiopathology
Subjects: diseases & disorders
diseases & disorders > mental disorders
diseases & disorders > mental disorders > mood disorders
diseases & disorders > mental disorders > mood disorders > depression
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: November 2004
Date Deposited: 04 Mar 2013 21:09
Last Modified: 04 Mar 2013 21:09
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27719

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