Neurogenesis and depression: etiology or epiphenomenon?

Henn, F. A., Vollmayr, B. (August 2004) Neurogenesis and depression: etiology or epiphenomenon? Biol Psychiatry, 56 (3). pp. 146-50. ISSN 0006-3223 (Print)0006-3223 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/15271582
DOI: 10.1016/j.biopsych.2004.04.011

Abstract

The concept that decreased neurogenesis might be the cause of depression is supported by the effects of stress on neurogenesis and the demonstration that neurogenesis seems to be necessary for antidepressant action. Data from the animal models tested to date show that decreasing the rate of neurogenesis does not lead to depressive behavior. Furthermore, evidence shows that an effective treatment for depression, transcranial magnetic stimulation, does not alter rates of neurogenesis. On the basis of these findings, it is suggested that neurogenesis might play a subtle role in depression but that it is not the primary factor in the final common pathway leading to depression.

Item Type: Paper
Uncontrolled Keywords: Animals Antidepressive Agents/therapeutic use Brain/ pathology Cell Division/physiology Depression/drug therapy/epidemiology/ etiology Disease Models, Animal Humans Neurons/ pathology Stress, Physiological/drug therapy/physiopathology Time Factors
Subjects: diseases & disorders
diseases & disorders > mental disorders
diseases & disorders > mental disorders > mood disorders
diseases & disorders > mental disorders > mood disorders > depression
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: 1 August 2004
Date Deposited: 04 Mar 2013 20:30
Last Modified: 04 Mar 2013 20:30
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27707

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