Alcohol consumption significantly influences the MR signal of frontal choline-containing compounds

Ende, G., Walter, S., Welzel, H., Demirakca, T., Wokrina, T., Ruf, M., Ulrich, M., Diehl, A., Henn, F. A., Mann, K. (August 2006) Alcohol consumption significantly influences the MR signal of frontal choline-containing compounds. Neuroimage, 32 (2). pp. 740-6. ISSN 1053-8119 (Print)1053-8119 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/16759881
DOI: 10.1016/j.neuroimage.2006.03.049

Abstract

The aim of this work was to evaluate the relationship between the amount of alcohol consumption of a group of social drinkers and the magnetic resonance spectroscopy signal of choline-containing compounds (Cho) in the frontal lobe. Two independent long echo (TE = 135 ms) (1)H MRSI studies, the first comprising 24 subjects with very low alcohol consumption, the second 18 subjects with a more widespread alcohol consumption were conducted. Significant correlations of Cho measures from frontal white matter and from the anterior cingulate gyrus with alcohol consumption in the last 90 days prior to the MR examination were found. Age, gender, and smoking did not show significant effects on the metabolite measures. Partialling out the effect of the voxel white matter content did not change the correlation of choline measures with alcohol consumption. The main conclusion from the repeated finding of a positive correlation of alcohol consumption and frontal Cho signals is that monitoring for alcohol consumption is mandatory in MRS studies where pathology depended Cho changes are hypothesized.

Item Type: Paper
Uncontrolled Keywords: Adult Alcohol Drinking/ adverse effects/physiopathology Choline/ metabolism Creatinine/metabolism Dominance, Cerebral/physiology Dose-Response Relationship, Drug Ethanol/ toxicity Female Frontal Lobe/ drug effects/physiopathology Gyrus Cinguli/drug effects/physiopathology Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Middle Aged
Subjects: Investigative techniques and equipment
organs, tissues, organelles, cell types and functions > tissues types and functions > frontal lobe
organism description > animal > mammal > primates > hominids > human
Investigative techniques and equipment > spectroscopy > magnetic resonance spectroscopy
organs, tissues, organelles, cell types and functions
Investigative techniques and equipment > spectroscopy
organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: 15 August 2006
Date Deposited: 01 Mar 2013 17:33
Last Modified: 01 Mar 2013 17:33
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27654

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