Elevated spectroscopic glutamate/gamma-amino butyric acid in rats bred for learned helplessness

Sartorius, A., Mahlstedt, M. M., Vollmayr, B., Henn, F. A., Ende, G. (September 2007) Elevated spectroscopic glutamate/gamma-amino butyric acid in rats bred for learned helplessness. Neuroreport, 18 (14). pp. 1469-73. ISSN 0959-4965 (Print)0959-4965 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/17712276
DOI: 10.1097/WNR.0b013e3282742153

Abstract

The theory of depression is dominated by the monoamine hypothesis but there is increasing evidence that beyond monoamines, glutamate (Glu) and gamma-aminobutyric acid (GABA) play an essential role in the pathogenesis of depression. In this study, the effect of alterations of GABA and Glu were investigated in the congenital learned helplessness paradigm. Proton magnetic resonance spectroscopy is an important monitoring tool to bridge the findings in clinical and preclinical studies. We found increased Glu/GABA ratios in the hippocampus and prefrontal cortex of placebo-treated (saline intraperitoneally) congenital learned helplessness rats versus wild-type rats, and a treatment-induced (desipramine 10 mg/kg intraperitoneally or electroconvulsive shock) decrease of this monoamine ratio in both brain regions. Our results corroborate previous findings of an amino-acid influence on the pathomechanisms of mood disorders.

Item Type: Paper
Uncontrolled Keywords: Animals Behavior, Animal Brain/metabolism/pathology Depression/ metabolism/pathology Disease Models, Animal Glutamic Acid/ metabolism Helplessness, Learned Magnetic Resonance Spectroscopy Rats Rats, Inbred Strains gamma-Aminobutyric Acid/ metabolism
Subjects: diseases & disorders
diseases & disorders > mental disorders
diseases & disorders > mental disorders > mood disorders
organism description > animal
diseases & disorders > mental disorders > mood disorders > depression
organism description > model organism
organism description > animal > mammal > rodent > rat
organism description > animal > mammal > rodent > rat
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: 17 September 2007
Date Deposited: 01 Mar 2013 14:13
Last Modified: 01 Mar 2013 14:13
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27646

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