RNAi, heterochromatin and the cell cycle

Kloc, A., Martienssen, R. (October 2008) RNAi, heterochromatin and the cell cycle. Trends in genetics, 24 (10). pp. 511-7. ISSN 0168-9525 (Print)0168-9525 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/18778867
DOI: 10.1016/j.tig.2008.08.002

Abstract

For many decades after its initial characterization, heterochromatin was considered to be transcriptionally inert, but newer work indicates that this highly condensed chromosomal material is transcribed, and rapidly silenced, by an orchestrated sequence of events directed by RNA interference (RNAi). Recent studies shed light on the timely assembly and inheritance of heterochromatin within a short period during the cell cycle, thereby providing an explanation for how 'silent' heterochromatin can be transcribed during the S phase of the cell cycle. Together, these findings suggest a model of RNAi-directed epigenetic inheritance.

Item Type: Paper
Uncontrolled Keywords: Animals Cell Cycle genetics DNA Transposable Elements physiology Epigenesis Genetic physiology Heterochromatin physiology Humans Models Biological RNA Interference physiology RNA Small Interfering physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > design
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > design > nucleic acid design
bioinformatics > genomics and proteomics > design > nucleic acid design > RNAI Design
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
CSHL Authors:
Communities: CSHL labs > Martienssen lab
Depositing User: Matt Covey
Date: October 2008
Date Deposited: 25 Feb 2013 19:49
Last Modified: 25 Feb 2013 19:49
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27617

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving