The quest for the 1p36 tumor suppressor

Bagchi, A., Mills, A. A. (2008) The quest for the 1p36 tumor suppressor. Cancer Res, 68 (8). pp. 2551-6.

URL: http://www.ncbi.nlm.nih.gov/pubmed/18413720
DOI: 10.1158/0008-5472.CAN-07-2095

Abstract

Genomic analyses of late-stage human cancers have uncovered deletions encompassing 1p36, thereby providing an extensive body of literature supporting the idea that a potent tumor suppressor resides in this interval. Although several genes have been proposed as 1p36 candidate tumor suppressors, convincing evidence that their encoded products protect from cancer has been scanty. A recent functional study identified chromodomain helicase DNA-binding protein 5 (CHD5) as a novel tumor suppressor mapping to 1p36. Here, we discuss evidence supporting the tumor-suppressive role of CHD5. Together, these findings suggest that strategies designed to enhance CHD5 activity could provide novel approaches for treating a broad range of human malignancies.

Item Type: Paper
Subjects: bioinformatics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > suppressor
CSHL Authors:
Communities: CSHL labs > Mills lab
Depositing User: Matt Covey
Date Deposited: 25 Feb 2013 21:50
Last Modified: 25 Feb 2013 21:50
PMCID: PMC2980353
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27599

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