Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory

Bolduc, F. V., Bell, K. G., Cox, H., Broadie, K. S., Tully, T. (October 2008) Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory. Nat Neurosci, 11 (10). 1143 - 1145 .

URL: http://www.ncbi.nlm.nih.gov/pubmed/18776892
DOI: 10.1038/nn.2175

Abstract

We used Drosophila olfactory memory as a model to study the molecular basis of cognitive defects in Fragile X syndrome in vivo. We observed that fragile X protein was acutely required and interacted with argonaute1 and staufen in the formation of long-term memory. Occlusion of long-term memory formation in Fragile X mutants could be rescued by protein synthesis inhibitors, suggesting that excess baseline protein synthesis could negatively affect cognition.

Item Type: Paper
Subjects: diseases & disorders > congenital hereditary genetic diseases
diseases & disorders
organism description > animal > insect > Drosophila
diseases & disorders > congenital hereditary genetic diseases > fragile X syndrome
organism description > animal > insect
organism description > animal behavior > memory
CSHL Authors:
Communities: CSHL labs > Tully lab
Watson School > Publications
Depositing User: Matt Covey
Date: October 2008
Date Deposited: 26 Feb 2013 20:30
Last Modified: 22 Sep 2014 15:48
PMCID: PMC3038669
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27526

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