Practical, ethical and regulatory considerations for the evolving medical and research genomics landscape.

Lyon, Gholson J., Segal, Jeremy P. (2013) Practical, ethical and regulatory considerations for the evolving medical and research genomics landscape. Applied & Translational Genomics, 2 (1). pp. 34-40. ISSN 2212-0661 (In Press)

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URL: https://www.ncbi.nlm.nih.gov/pubmed/27942444
DOI: 10.1016/j.atg.2013.02.001

Abstract

We are entering a fascinating and uncertain period of medical history, as today’s DNA sequencing technology has the potential to help each of us direct our care and predict our future based on knowledge of our own individual inherited and acquired genetics. However, from a global and local economic perspective, these are lean years, and this adds a significant degree of uncertainty to the immediate future of this enterprise. It is therefore incumbent upon us as a community to show that personalized genomic medicine will not just be a luxury or a burdensome cost center, but that it truly has the potential to save both lives and health care expenses via data-driven management, early disease detection/screening and more efficacious pharmaceutical delivery. To do this, we need to determine how to move forward towards expanded clinical use of this technology in a manner both rapid and economical, while ensuring the integrity of the process and the safety and well-being of patients and research participants. Here, we discuss some of the ethical, regulatory and practical considerations that are emerging in the field of genomic medicine. We also propose that many of the cost and safety issues we are facing can be mitigated through expanded reliance on existing clinical regulatory frameworks and the implementation of worksharing strategies designed to leverage the strengths of our genomics centers and clinical interpretive teams.

Item Type: Paper
Subjects: bioinformatics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes
bioinformatics > genomics and proteomics > personal genomes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes > personal genomes
CSHL Authors:
Communities: CSHL labs > Lyon lab
Depositing User: Matt Covey
Date Deposited: 14 Feb 2013 14:40
Last Modified: 01 Feb 2017 17:35
PMCID: PMC5133337
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27479

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