Targeting the Kinome II

Hemmings, B. A., Restuccia, D., Tonks, N. K. (April 2009) Targeting the Kinome II. Curr Opin Cell Biol, 21 (2). pp. 135-139.

URL: http://www.ncbi.nlm.nih.gov/pubmed/19342212
DOI: 10.1016/j.ceb.2009.03.001

Abstract

The topic of this edition of Current Opinion in Cell Biology originated some 22 years ago in Basel, when Novartis gave approval for an ambitious project to isolate protein kinase inhibitors. The first fruit of this research was the development of Glivec, an inhibitor of the Abl tyrosine kinase. While originally registered for treatment of Philadelphia chromosome-positive chronic myeloid leukemia (CML), the identification of several other tyrosine kinases that it effectively inhibits has seen its application extended to other malignancies, including the often inoperable and metastatic GIST type of gastrointestinal cancer. In 2006, the 20th anniversary of that Novartis decision, another ambitious project brought the leading experts in protein kinase inhibitor research to Basel for a meeting to celebrate this odyssey. Over 600 scientists from 30 different countries heard 36 presentations on all aspects of kinase biology (see details on the meeting report by Bozulic et al. [1]). Against this background, this issue revisits many of the areas discussed at the 2006 meeting. Overall, 23 articles written by former speakers on the 2006 program are presented, highlighting significant advances in the development of additional Kinome-targeted therapies.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL labs > Tonks lab
Depositing User: Matt Covey
Date: April 2009
Date Deposited: 15 Feb 2013 20:02
Last Modified: 15 Feb 2013 20:02
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27468

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