Reactome knowledgebase of human biological pathways and processes

Matthews, L., Gopinath, G., Gillespie, M., Caudy, M., Croft, D., de Bono, B., Garapati, P., Hemish, J., Hermjakob, H., Jassal, B., Kanapin, A., Lewis, S., Mahajan, S., May, B., Schmidt, E., Vastrik, I., Wu, G., Birney, E., Stein, L. D., D'Eustachio, P. (January 2009) Reactome knowledgebase of human biological pathways and processes. Nucleic Acids Res, 37. D619-22.

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URL: http://www.ncbi.nlm.nih.gov/pubmed/18981052
DOI: 10.1093/nar/gkn863

Abstract

Reactome (http://www.reactome.org) is an expert-authored, peer-reviewed knowledgebase of human reactions and pathways that functions as a data mining resource and electronic textbook. Its current release includes 2975 human proteins, 2907 reactions and 4455 literature citations. A new entity-level pathway viewer and improved search and data mining tools facilitate searching and visualizing pathway data and the analysis of user-supplied high-throughput data sets. Reactome has increased its utility to the model organism communities with improved orthology prediction methods allowing pathway inference for 22 species and through collaborations to create manually curated Reactome pathway datasets for species including Arabidopsis, Oryza sativa (rice), Drosophila and Gallus gallus (chicken). Reactome's data content and software can all be freely used and redistributed under open source terms.

Item Type: Paper
Uncontrolled Keywords: Algorithms Chromosomes, Artificial, Bacterial Comparative Genomic Hybridization/statistics & numerical data Models, Genetic Oligonucleotide Array Sequence Analysis/statistics & numerical data Physical Chromosome Mapping/statistics & numerical data Schizosaccharomyces/*genetics Sequence Analysis, DNA/statistics & numerical data
Subjects: bioinformatics
bioinformatics > genomics and proteomics > databases
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > databases > databases
organism description > animal > mammal > primates > hominids > human
CSHL Authors:
Communities: CSHL labs > Stein lab
Depositing User: Matt Covey
Date: January 2009
Date Deposited: 19 Feb 2013 21:34
Last Modified: 19 Feb 2013 21:34
PMCID: PMC2686536
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27440

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