Moderate traumatic brain injury promotes proliferation of quiescent neural progenitors in the adult hippocampus

Gao, X., Enikolopov, G. N., Chen, J. (October 2009) Moderate traumatic brain injury promotes proliferation of quiescent neural progenitors in the adult hippocampus. Experimental Neurology, 219 (2). pp. 516-523.

URL: http://www.ncbi.nlm.nih.gov/pubmed/19615997
DOI: 10.1016/j.expneurol.2009.07.007

Abstract

Recent evidence shows that traumatic brain injury (TBI) regulates proliferation of neural stem/progenitor cells in the dentate gyrus (DG) of adult hippocampus. There are distinct classes of neural stem/progenitor cells in the adult DG, including quiescent neural progenitors (QNPs), which carry stem cell properties, and their progeny, amplifying neural progenitors (ANPs). The response of each class of progenitors to TBI is not clear. We here used a transgenic reporter Nestin-GFP mouse line, in which QNP and ANP cells are easily visualized and quantified, to determine the targets of the TBI in the DG. We examined changes in proliferation of QNPs and ANPs in the acute phase following TBI and found that QNPs were induced by TBI insult to enter the cell cycle whereas proliferation of ANPs was not significantly affected. These results indicate that different subtypes of neural stem/progenitor cells respond differently to TBI insult. Stem cell activation by the TBI may reflect the induction of innate repair and plasticity mechanisms by the injured brain.

Item Type: Paper
Uncontrolled Keywords: Traumatic brain injury Neural stem/progenitor Proliferation Transgenic mice
Subjects: organs, tissues, organelles, cell types and functions > organs types and functions > brain
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
neurobiology
organs, tissues, organelles, cell types and functions > organs types and functions
organs, tissues, organelles, cell types and functions
therapies > stem cells
organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:
Communities: CSHL labs > Enikopolov lab
CSHL Cancer Center Shared Resources > Animal Services
Depositing User: Matt Covey
Date: October 2009
Date Deposited: 20 Feb 2013 17:16
Last Modified: 29 Dec 2014 17:02
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27417

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving