Damage control: DNA repair, transcription, and the ubiquitin-proteasome system

Daulny, A., Tansey, W. P. (April 2009) Damage control: DNA repair, transcription, and the ubiquitin-proteasome system. DNA Repair, 8 (4). pp. 444-448.

URL: http://www.ncbi.nlm.nih.gov/pubmed/19272841
DOI: 10.1016/j.dnarep.2009.01.017

Abstract

The presence of DNA damage within an actively transcribed gene poses an immediate threat to cellular viability. Bulky DNA adducts, such as those induced by ultraviolet light, can profoundly influence patterns of gene expression by causing the irreversible arrest of RNA polymerase II at sites of DNA damage. It is critical that processes exist to either specifically repair transcribed genes or clear stalled RNA polymerase, so that general repair can occur and transcription resume. A growing body of evidence indicates that clearance of stalled polymerase is achieved, in part, by ubiquitin-mediated destruction of the largest subunit of RNA polymerase II. In this review, we shall discuss how an intimate connection between RNA polymerase II and the ubiquitylation machinery acts to restore normal transcription after DNA damage, and other forms of transcriptional arrest, has occurred.

Item Type: Paper
Uncontrolled Keywords: RNA polymerase II Ubiquitin DNA damage Transcription elongation
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
CSHL Authors:
Communities: CSHL labs > Tansey lab
Depositing User: Matt Covey
Date: 5 April 2009
Date Deposited: 21 Feb 2013 17:04
Last Modified: 21 Feb 2013 17:04
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27353

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