Curing "incurable" Cancer

Watson, J. D. (November 2011) Curing "incurable" Cancer. Cancer Discovery, 1 (6). pp. 477-480. ISSN 2159-8274

URL: http://www.ncbi.nlm.nih.gov/pubmed/22586652
DOI: 10.1158/2159-8290.cd-11-0220

Abstract

Cancer cells are preferentially killed by anticancer agents because key signals for growth and cell division are "always on" as opposed to the alternative "on" and "off" signaling of normal cells. Too much of today's anticancer drug discovery effort may go toward reversing genetically promoted "always on" signals. More effective anticancer drug targets may be found through use of RNAi technologies that pinpoint the key gene regulatory and metabolic weakness of the "always on" cancer cells. Cancer Discovery; 1(6); 477-80. (C) 2011 AACR.

Item Type: Paper
Uncontrolled Keywords: met protooncogene tumor suppression growth pathway inhibition resistance mechanisms metformin therapy cells
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
diseases & disorders
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
therapies
therapies > cancer drugs - see diseases-cancer-drugs and therapies
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: November 2011
Date Deposited: 05 Feb 2013 20:47
Last Modified: 05 Feb 2013 20:47
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27214

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