Mitochondrial capture by a transmissible cancer

Rebbeck, C. A., Leroi, A. M., Burt, A. (2011) Mitochondrial capture by a transmissible cancer. Science, 331 (6015). p. 303.

URL: http://www.ncbi.nlm.nih.gov/pubmed/21252340
DOI: 10.1126/science.1197696

Abstract

anine transmissible venereal tumor (CTVT) is an infectious cell line circulating in many feral dog populations. It originated once, about 10,000 years ago. Phylogenetic analyses of mitochondrial sequences from dogs, wolves, and a geographically diverse collection of CTVT samples indicate that the cancer has periodically acquired mitochondria from its host. We suggest that this may be because the cancer's own mitochondria have a tendency to degenerate, due to high mutation rates and relaxed selection, resulting in host mitochondria being more fit.

Item Type: Paper
Subjects: diseases & disorders > cancer
diseases & disorders
organs, tissues, organelles, cell types and functions > organelles, types and functions > mitochondria
organs, tissues, organelles, cell types and functions > organelles, types and functions
organs, tissues, organelles, cell types and functions
CSHL Authors:
Communities: CSHL labs > Hannon lab
CSHL Post Doctoral Fellows
Depositing User: Matt Covey
Date Deposited: 06 Feb 2013 14:44
Last Modified: 03 May 2013 14:02
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27193

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