Muthuswamy, S. K. (April 2011) Trastuzumab resistance: all roads lead to SRC. Nature Medicine, 17 (4). pp. 416-8. ISSN 1078-8956
DOI: 10.1038/nm0411-416
Abstract
A new study shows how SRC, a nonmembrane tyrosine kinase, is a common signaling node in trastuzumab resistance caused by different mechanisms in HER2-positive breast cancers (pages 461–469). A SRC inhibitor restored trastuzumab sensitivity in vitro and in mouse tumor models, suggesting a new way to tackle drug resistance in breast tumors.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer diseases & disorders therapies diseases & disorders > cancer > cancer types > breast cancer therapies > cancer drugs - see diseases-cancer-drugs and therapies diseases & disorders > cancer > cancer types |
| CSHL Authors: | |
| Communities: | CSHL labs > Muthuswamy lab |
| Depositing User: | Matt Covey |
| Date: | April 2011 |
| Date Deposited: | 06 Feb 2013 19:24 |
| Last Modified: | 06 Feb 2013 19:24 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27180 |
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