RNA interference and heterochromatin assembly

Volpe, T., Martienssen, R. A. (September 2011) RNA interference and heterochromatin assembly. Cold Spring Harbor perspectives in biology, 3 (9). a003731. ISSN 1943-0264 (Electronic)

URL: http://www.ncbi.nlm.nih.gov/pubmed/21441597
DOI: 10.1101/cshperspect.a003731

Abstract

In most eukaryotes, histone and DNA modifications are responsible for the silencing of genes integrated in heterochromatic sequences, as well as the silencing of pericentromeric repeats and transposable elements themselves. But the mechanisms that guide these modifications to heterochromatin during the cell cycle have been elusive. RNA interference takes advantage of heterochromatic transcription to process small RNAs and recruit enzymes required for both histone and DNA modifications, and is one such mechanism that has been identified. The processes are best understood in fission yeast and plants, but recent work in mammalian cells, especially in the germline, suggests these mechanisms may be highly conserved.

Item Type: Paper
Uncontrolled Keywords: Animals Cell Cycle physiology Drosophila Heterochromatin physiology Histones metabolism Models Biological RNA Interference Schizosaccharomyces
Subjects: bioinformatics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
CSHL Authors:
Communities: CSHL labs > Martienssen lab
Depositing User: Matt Covey
Date: September 2011
Date Deposited: 06 Feb 2013 21:36
Last Modified: 09 Apr 2014 19:06
PMCID: PMC3181039
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27163

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