Rhind, N., Chen, Z., Yassour, M., Thompson, D. A., Haas, B. J., Habib, N., Wapinski, I., Roy, S., Lin, M. F., Heiman, D. I., Young, S. K., Furuya, K., Guo, Y., Pidoux, A., Chen, H. M., Robbertse, B., Goldberg, J. M., Aoki, K., Bayne, E. H., Berlin, A. M., Desjardins, C. A., Dobbs, E., Dukaj, L., Fan, L., FitzGerald, M. G., French, C., Gujja, S., Hansen, K., Keifenheim, D., Levin, J. Z., Mosher, R. A., Muller, C. A., Pfiffner, J., Priest, M., Russ, C., Smialowska, A., Swoboda, P., Sykes, S. M., Vaughn, M., Vengrova, S., Yoder, R., Zeng, Q., Allshire, R., Baulcombe, D., Birren, B. W., Brown, W., Ekwall, K., Kellis, M., Leatherwood, J., Levin, H., Margalit, H., Martienssen, R., Nieduszynski, C. A., Spatafora, J. W., Friedman, N., Dalgaard, J. Z., Baumann, P., Niki, H., Regev, A., Nusbaum, C. (May 2011) Comparative functional genomics of the fission yeasts. Science, 332 (6032). pp. 930-6. ISSN 1095-9203 (Electronic)0036-8075 (Linking)
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Abstract
The fission yeast clade--comprising Schizosaccharomyces pombe, S. octosporus, S. cryophilus, and S. japonicus--occupies the basal branch of Ascomycete fungi and is an important model of eukaryote biology. A comparative annotation of these genomes identified a near extinction of transposons and the associated innovation of transposon-free centromeres. Expression analysis established that meiotic genes are subject to antisense transcription during vegetative growth, which suggests a mechanism for their tight regulation. In addition, trans-acting regulators control new genes within the context of expanded functional modules for meiosis and stress response. Differences in gene content and regulation also explain why, unlike the budding yeast of Saccharomycotina, fission yeasts cannot use ethanol as a primary carbon source. These analyses elucidate the genome structure and gene regulation of fission yeast and provide tools for investigation across the Schizosaccharomyces clade.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Centromere genetics physiology ultrastructure DNA Transposable Elements Evolution Molecular Gene Expression Profiling Gene Expression Regulation Fungal Genes Mating Type Fungal Genome Fungal Genomics Glucose metabolism Meiosis Molecular Sequence Annotation Molecular Sequence Data Phylogeny RNA Antisense genetics RNA Fungal genetics RNA Small Interfering genetics RNA Untranslated genetics Regulatory Elements Transcriptional Schizosaccharomyces genetics growth & development metabolism Schizosaccharomyces pombe Proteins genetics metabolism Sequence Analysis DNA Species Specificity Transcription Factors genetics metabolism Transcription Genetic |
| Subjects: | bioinformatics bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes organism description > yeast |
| CSHL Authors: | |
| Communities: | CSHL labs > Martienssen lab CSHL Cancer Center Shared Resources > DNA Sequencing Service |
| Depositing User: | Matt Covey |
| Date: | 20 May 2011 |
| Date Deposited: | 06 Feb 2013 21:34 |
| Last Modified: | 02 Oct 2019 15:26 |
| PMCID: | PMC3131103 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27162 |
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