Compartmentalized versus global synaptic plasticity on dendrites controlled by experience

Makino, H., Malinow, R. (2011) Compartmentalized versus global synaptic plasticity on dendrites controlled by experience. Neuron, 72 (6). pp. 1001-1011. ISSN 08966273 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/22196335
DOI: 10.1016/j.neuron.2011.09.036

Abstract

Synapses in the brain are continuously modified by experience, but the mechanisms are poorly understood. In vitro and theoretical studies suggest threshold-lowering interactions between nearby synapses that favor clustering of synaptic plasticity within a dendritic branch. Here, a fluorescently tagged AMPA receptor-based optical approach was developed permitting detection of single-synapse plasticity in mouse cortex. Sensory experience preferentially produced synaptic potentiation onto nearby dendritic synapses. Such clustering was significantly reduced by expression of a phospho-mutant AMPA receptor that is insensitive to threshold-lowering modulation for plasticity-driven synaptic incorporation. In contrast to experience, sensory deprivation caused homeostatic synaptic enhancement globally on dendrites. Clustered synaptic potentiation produced by experience could bind behaviorally relevant information onto dendritic subcompartments; global synaptic upscaling by deprivation could equally sensitize all dendritic regions for future synaptic input. © 2011 Elsevier Inc.

Item Type: Paper
Subjects: organism description > animal behavior
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
organs, tissues, organelles, cell types and functions > cell types and functions
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity
organs, tissues, organelles, cell types and functions
CSHL Authors:
Communities: CSHL labs > Malinow lab
Watson School > Publications
Depositing User: Matt Covey
Date: 2011
Date Deposited: 06 Feb 2013 21:19
Last Modified: 22 Sep 2014 20:08
PMCID: PMC3310180
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27160

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving