The Tuberous Sclerosis Complex-Mammalian Target of Rapamycin Pathway Maintains the Quiescence and Survival of Naive T Cells

Wu, Q., Liu, Y., Chen, C., Ikenoue, T., Qiao, Y., Li, C. S., Li, W. Q., Guan, K. L., Zheng, P. (August 2011) The Tuberous Sclerosis Complex-Mammalian Target of Rapamycin Pathway Maintains the Quiescence and Survival of Naive T Cells. Journal of Immunology, 187 (3). pp. 1106-1112. ISSN 0022-1767

Abstract

Naive T cells receive stimulation from the positive selecting ligand in the periphery for their survival. This stimulation does not normally lead to overt activation of T cells, as the T cells remain largely quiescent until they receive either antigenic or lymphopenic stimuli. The underlying mechanism responsible for survival and quiescence of the naive T cells remains largely unknown. In this study, we report that T cell-specific deletion of Tsc1, a negative regulator of mammalian target of rapamycin, resulted in both spontaneous losses of quiescence and cellularity, especially within the CD8 subset. The Tsc1-deficient T cells have increased cell proliferation and apoptosis. Tsc1 deletion affects the survival and quiescence of T cells in the absence of antigenic stimulation. Loss of quiescence but not cellularity was inhibited by rapamycin. Our data demonstrate that tuberous sclerosis complex-mammalian target of rapamycin maintains quiescence and survival of T cells.

Item Type:	Paper
Uncontrolled Keywords:	hematopoietic stem-cells lineage commitment binding partner kinase-activity rag gtpases mtor receptor memory protein raptor
Subjects:	organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types
CSHL Authors:	Chen, Chong Liu, Yu
Communities:	CSHL labs > Lowe lab
Depositing User:	Matt Covey
Date:	August 2011
Date Deposited:	06 Feb 2013 20:43
Last Modified:	06 Feb 2013 20:43
PMCID:	PMC3151493
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/27156

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