Nucleating actin for invasion

Nurenberg, A., Kitzing, T. M., Grosse, R. (March 2011) Nucleating actin for invasion. Nature Reviews Cancer, 11 (3). pp. 177-187. ISSN 1474-175X

URL: http://www.ncbi.nlm.nih.gov/pubmed/21326322
DOI: 10.1038/nrc3003

Abstract

The invasion of cancer cells into the surrounding tissue is a prerequisite and initial step in metastasis, which is the leading cause of death from cancer. Invasive cell migration requires the formation of various structures, such as invadopodia and pseudopodia, which require actin assembly that is regulated by specialized actin nucleation factors. There is a large variety of different actin nucleators in human cells, such as formins, spire and Arp2/3-regulating proteins, and the list is likely to grow. Studies of the mechanisms of various actin nucleation factors that are involved in cancer cell function may ultimately provide new treatments for invasive and metastatic disease.

Item Type: Paper
Uncontrolled Keywords: squamous-cell carcinoma aldrich-syndrome protein growth-factor receptor extracellular-matrix degradation chromosome 11q13 amplification primary mammary-tumors prostate-cancer cells primary breast-cancer n-wasp arp2/3 complex
Subjects: bioinformatics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > actin
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL labs > Lowe lab
Depositing User: Matt Covey
Date: March 2011
Date Deposited: 06 Feb 2013 22:27
Last Modified: 06 Feb 2013 22:27
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27144

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