MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer

Png, K. J., Yoshida, M., Zhang, X. H. F., Shu, W., Lee, H., Rimner, A., Chan, T. A., Comen, E., Andrade, V. P., Kim, S. W., King, T. A., Hudis, C. A., Norton, L., Hicks, J. B., Massagué, J., Tavazoie, S. F. (February 2011) MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer. Genes and Development, 25 (3). pp. 226-231. ISSN 08909369

URL: http://www.ncbi.nlm.nih.gov/pubmed/21289068
DOI: 10.1101/gad.1974211

Abstract

Post-transcriptional regulators have emerged as robust effectors of metastasis and display deregulated expression through unknown mechanisms. Here, we reveal that the human microRNA-335 locus undergoes genetic deletion and epigenetic promoter hypermethylation in every metastatic derivative obtained from independent patients' malignant cell populations. Genetic deletion of miR-335 is a common event in human breast cancer, is enriched for in breast cancer metastases, and also correlates with ovarian cancer recurrence. We furthermore identify miR-335 as a robust inhibitor of tumor reinitiation. We thus implicate the miR-335 locus on 7q32.2 as the first selective metastasis suppressor and tumor initiation suppressor locus in human breast cancer. © 2011 by Cold Spring Harbor Laboratory Press.

Item Type: Paper
Uncontrolled Keywords: Epigenetic Genetic Metastasis miR-335 Ovarian Tumor intiation
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
diseases & disorders
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
diseases & disorders > cancer > cancer types > breast cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA

diseases & disorders > cancer > cancer types
CSHL Authors:
Communities: CSHL Cancer Center Shared Resources > Instrumentation Service
CSHL labs > Hicks lab
CSHL Cancer Center Program > Cancer Genetics
Depositing User: Matt Covey
Date: 1 February 2011
Date Deposited: 07 Feb 2013 16:16
Last Modified: 14 Oct 2015 20:16
PMCID: PMC3034897
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27134

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