The persistence of a silent memory

Zaratiegui, M., Martienssen, R. (February 2012) The persistence of a silent memory. Nature genetics, 44 (2). pp. 118-9. ISSN 1546-1718 (Electronic)1061-4036 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/22281766
DOI: 10.1038/ng.1088

Abstract

One of the most striking properties of RNA interference (RNAi) in Caenorhabditis elegans is its persistence in offspring after the triggering double-stranded RNA (dsRNA) has disappeared. A new study reveals that a heterochromatic silencing mark is deposited around the targets of RNAi and is transmitted through generations. These results show that RNAi can induce stable and heritable chromatin modifications in animals.

Item Type: Paper
Uncontrolled Keywords: Animals Caenorhabditis elegans metabolism Caenorhabditis elegans Proteins metabolism Histones metabolism Lysine metabolism RNA Small Interfering metabolism
Subjects: organism description > animal > C elegans
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
Investigative techniques and equipment
bioinformatics > genomics and proteomics > design > nucleic acid design
Investigative techniques and equipment > RNAI
bioinformatics > genomics and proteomics > design > nucleic acid design > RNAI Design
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
organism description > animal
CSHL Authors:
Communities: CSHL labs > Martienssen lab
Depositing User: Matt Covey
Date: February 2012
Date Deposited: 17 Jan 2013 17:52
Last Modified: 17 Jan 2013 17:52
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27092

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