Epidermal growth factor receptor is a preferred target for treating Amyloid-beta-induced memory loss

Wang, L., Chiang, H. C., Wu, W. J., Liang, B., Xie, Z. L., Yao, X. S., Ma, W. W., Du, S. W., Zhong, Y. (October 2012) Epidermal growth factor receptor is a preferred target for treating Amyloid-beta-induced memory loss. Proceedings of the National Academy of Sciences of the United States of America, 109 (41). pp. 16743-16748. ISSN 0027-8424

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URL: http://www.ncbi.nlm.nih.gov/pubmed/23019586
DOI: 10.1073/pnas.1208011109

Abstract

Current understanding of amyloid-beta (A beta) metabolism and toxicity provides an extensive list of potential targets for developing drugs for treating Alzheimer's disease. We took two independent approaches, including synaptic-plasticity-based analysis and behavioral screening of synthetic compounds, for identifying single compounds that are capable of rescuing the A beta-induced memory loss in both transgenic fruit fly and transgenic mouse models. Two clinically available drugs and three synthetic compounds not only showed positive effects in behavioral tests but also antagonized the A beta oligomers-induced activation of the epidermal growth factor receptor (EGFR). Such surprising converging outcomes from two parallel approaches lead us to conclude that EGFR is a preferred target for treating A beta-induced memory loss.

Item Type: Paper
Uncontrolled Keywords: alzheimers-disease transgenic mice egf receptor mouse model synaptic plasticity cancer-therapy zd1839 iressa lung-cancer protein drosophila
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > epidermal growth factor
organism description > animal behavior > memory
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL labs > Zhong lab
Depositing User: Matt Covey
Date: October 2012
Date Deposited: 18 Jan 2013 15:07
Last Modified: 22 Dec 2017 17:14
PMCID: PMC3478595
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27074

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