Silent decision: HP1 protein escorts heterochromatic RNAs to their destiny

Ren, J., Martienssen, R. A. (August 2012) Silent decision: HP1 protein escorts heterochromatic RNAs to their destiny. Embo Journal, 31 (15). pp. 3237-8. ISSN 0261-4189

URL: http://www.ncbi.nlm.nih.gov/pubmed/22705945
DOI: 10.1038/emboj.2012.172

Abstract

Heterochromatin is classically perceived to be refractory to transcription because of its compact structure. However, Keller et al (2012) now demonstrated that heterochromatic transcripts can accumulate even when heterochromatin is normally packaged. By tracking down the fate of these heterochromatic RNAs, they revealed a new post-transcriptional mechanism of silencing in heterochromatin that involves the dynamic turnover of HP1Swi6 between its free, chromatin-bound and RNA-bound forms. The latter form escorts heterochromatic RNA to degradation...

Item Type: Paper
Uncontrolled Keywords: gene maintenance mechanisms disinhibition G protein-coupled receptor neuropathic pain oligomer spinal cord heterochromatin protein 1 RNA article gene silencing genetic transcription heterochromatin human molecular dynamics molecular mechanics nonhuman priority journal protein structure Rattus
Subjects: bioinformatics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA regulation
CSHL Authors:
Communities: CSHL labs > Martienssen lab
CSHL Post Doctoral Fellows
Depositing User: Matt Covey
Date: 1 August 2012
Date Deposited: 30 Jan 2013 14:33
Last Modified: 05 Jun 2013 20:03
PMCID: PMC3411077
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27027

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