Cell signaling and gene regulation

Paszkowski, J., Martienssen, R. A. (2012) Cell signaling and gene regulation. Current Opinion in Plant Biology, 15 (5). pp. 493-495. ISSN 1369-5266

URL: http://www.ncbi.nlm.nih.gov/pubmed/23141671
DOI: 10.1016/j.pbi.2012.10.002

Abstract

In 1983, Barbara McClintock concluded her Noble Lecture ‘THE SIGNIFICANCE OF RESPONSES OF THE GENOME TO CHALLENGE’ with the following statement: ‘In the future, attention undoubtedly will be centered on the genome, and with greater appreciation of its significance as a highly sensitive organ of the cell, monitoring genomic activities and correcting common errors, sensing the unusual and unexpected events, and responding to them, often by restructuring the genome.’ So far the most intensely studied part of this ‘highly sensitive organ of the cell’ consists of genes coding for proteins. We now know a great deal about their structures, their transcriptional regulation, the processing of transcripts, and the biological activities of their end products — the proteins. A further part of this ‘organ’ encodes transcripts that have various cellular activities as RNAs, mostly through association with proteins and the formation of multi-molecular complexes or structures. These range from very basic splicing and translation to the regulation of crucial developmental switches in the life cycle of multicellular eukaryotes. However, these two aspects of the ‘organ’ typically constitute only a small fraction of its volume.....

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell signaling
organs, tissues, organelles, cell types and functions > cell types and functions
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
organs, tissues, organelles, cell types and functions
organism description > plant
CSHL Authors:
Communities: CSHL labs > Martienssen lab
Depositing User: Matt Covey
Date Deposited: 29 Jan 2013 16:40
Last Modified: 29 Jan 2013 16:40
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27019

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