Cell Polarity as a Regulator of Cancer Cell Behavior Plasticity

Muthuswamy, S. K., Xue, B. (August 2012) Cell Polarity as a Regulator of Cancer Cell Behavior Plasticity. Annu Rev Cell Dev Biol, 28 (28). pp. 599-625. ISSN 1530-8995 (Electronic)1081-0706 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/22881459
DOI: 10.1146/annurev-cellbio-092910-154244

Abstract

Cell polarization is an evolutionarily conserved process that facilitates asymmetric distribution of organelles and proteins and that is modified dynamically during physiological processes such as cell division, migration, and morphogenesis. The plasticity with which cells change their behavior and phenotype in response to cell intrinsic and extrinsic cues is an essential feature of normal physiology. In disease states such as cancer, cells lose their ability to behave normally in response to physiological cues. A molecular understanding of mechanisms that alter the behavior of cancer cells is limited. Cell polarity proteins are a recognized class of molecules that can receive and interpret both intrinsic and extrinsic signals to modulate cell behavior. In this review, we discuss how cell polarity proteins regulate a diverse array of biological processes and how they can contribute to alterations in the behavior of cancer cells. Expected final online publication date for the Annual Review of Cell and Developmental Biology Volume 28 is October 06, 2012. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.

Item Type: Paper
Subjects: diseases & disorders > cancer
diseases & disorders
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell polarity
organs, tissues, organelles, cell types and functions > cell types and functions
CSHL Authors:
Communities: CSHL labs > Muthuswamy lab
Depositing User: Matt Covey
Date: 6 August 2012
Date Deposited: 30 Jan 2013 16:35
Last Modified: 30 Jan 2013 16:35
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27009

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