Autocrine prolactin: an emerging market for homegrown (prolactin) despite the imports

Muthuswamy, S. K. (October 2012) Autocrine prolactin: an emerging market for homegrown (prolactin) despite the imports. Genes Dev, 26 (20). pp. 2253-8. ISSN 1549-5477 (Electronic)0890-9369 (Linking)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/23070811
DOI: 10.1101/gad.204636.112

Abstract

Prolactin (PRL) is a peptide hormone that is produced by the pituitary gland and is known to regulate lactogenic differentiation. There is a significant body of evidence that points to autocrine production of prolactin and activation of an autocrine/paracrine signaling pathway to regulate cell proliferation and migration and inhibition of cell death. This perspective highlights the recent study in the October 1, 2012, issue of Genes & Development by Chen and colleagues (pp. 2154-2168) that describes a mechanism for autocrine prolactin production and places the finding in the context of a role for prolactin in breast development and cancer.

Item Type: Paper
Subjects: diseases & disorders > cancer
diseases & disorders
organs, tissues, organelles, cell types and functions > organs types and functions > breast
diseases & disorders > cancer > cancer types > breast cancer
organs, tissues, organelles, cell types and functions > organs types and functions
diseases & disorders > cancer > cancer types
CSHL Authors:
Communities: CSHL labs > Muthuswamy lab
Depositing User: Matt Covey
Date: 15 October 2012
Date Deposited: 30 Jan 2013 16:32
Last Modified: 03 Nov 2017 20:01
PMCID: PMC3475797
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27008

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