An effort to make sense of antisense transcription in bacteria

Lasa, I., Toledo-Arana, A., Gingeras, T. R. (August 2012) An effort to make sense of antisense transcription in bacteria. RNA Biology, 9 (8). pp. 1039-1044. ISSN 1547-6286

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URL: http://www.ncbi.nlm.nih.gov/pubmed/22858676
DOI: 10.4161/rna.21167

Abstract

Analysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some portion of the 5'- and 3'-UTR regions. The biological advantages of such overlapping transcription are unclear but may play important regulatory roles at the level of transcription, RNA stability and translation. In a recent report, the human pathogen Staphylococcus aureus is observed to generate genome-wide overlapping transcription in the same bacterial cells leading to a collection of short RNA fragments generated by the endoribonuclease III, RNase III. This processing appears most prominently in Gram-positive bacteria. The implications of both the use of pervasive overlapping transcription and the processing of these double stranded templates into short RNAs are explored and the consequences discussed.

Item Type: Paper
Uncontrolled Keywords: overlapping transcription RNase III RNA processing bacteria transcriptome highly conserved protein messenger-rna escherichia-coli gene-regulation start sites genome degradation virulence interference expression
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > antisense
organism description > bacteria
CSHL Authors:
Communities: CSHL labs > Gingeras lab
Depositing User: Matt Covey
Date: August 2012
Date Deposited: 30 Jan 2013 17:12
Last Modified: 06 Apr 2015 19:10
PMCID: PMC3551857
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26986

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