Evoked axonal oxytocin release in the central amygdala attenuates fear response

Knobloch, H. S., Charlet, A., Hoffmann, L., Eliava, M., Khrulev, S., Cetin, A., Osten, P., Schwarz, M., Seeburg, P., Stoop, R., Grinevich, V. (February 2012) Evoked axonal oxytocin release in the central amygdala attenuates fear response. Neuron, 73 (3). pp. 553-566. ISSN 08966273 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/22325206
DOI: 10.1016/j.neuron.2011.11.030

Abstract

The hypothalamic neuropeptide oxytocin (OT), which controls childbirth and lactation, receives increasing attention for its effects on social behaviors, but how it reaches central brain regions is still unclear. Here we gained by recombinant viruses selective genetic access to hypothalamic OT neurons to study their connectivity and control their activity by optogenetic means. We found axons of hypothalamic OT neurons in the majority of forebrain regions, including the central amygdala (CeA), a structure critically involved in OT-mediated fear suppression. Invitro, exposure to blue light of channelrhodopsin-2-expressing OT axons activated a local GABAergic circuit that inhibited neurons in the output region of the CeA. Remarkably, invivo, local blue-light-induced endogenous OT release robustly decreased freezing responses in fear-conditioned rats. Our results thus show widespread central projections of hypothalamic OT neurons and demonstrate that OT release from local axonal endings can specifically control region-associated behaviors. © 2012 Elsevier Inc.

Item Type: Paper
Subjects: organism description > animal behavior
organs, tissues, organelles, cell types and functions > tissues types and functions > axon
organism description > animal behavior > fear
organs, tissues, organelles, cell types and functions
organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:
Communities: CSHL labs > Osten lab
Depositing User: Matt Covey
Date: 9 February 2012
Date Deposited: 30 Jan 2013 19:43
Last Modified: 30 Jan 2013 19:43
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26977

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