A Permissive Role of Mushroom Body α/β Core Neurons in Long-Term Memory Consolidation in Drosophila

Huang, C. , Zheng, X., Zhao, H., Li, M., Wang, P. , Xie, Z., Wang, L., Zhong, Y. (November 2012) A Permissive Role of Mushroom Body α/β Core Neurons in Long-Term Memory Consolidation in Drosophila. Current Biology, 22 (21). pp. 1981-1989. ISSN 0960-9822

URL: http://www.ncbi.nlm.nih.gov/pubmed/23063437
DOI: 10.1016/j.cub.2012.08.048

Abstract

BACKGROUND: Memories are not created equally strong or persistent for different experiences. In Drosophila, induction of long-term memory (LTM) for aversive olfactory conditioning requires ten spaced repetitive training trials, whereas a single trial is sufficient for LTM generation in appetitive olfactory conditioning. Although, with the ease of genetic manipulation, many genes and brain structures have been related to LTM formation, it is still an important task to identify new components and reveal the mechanisms underlying LTM regulation. RESULTS: Here we show that single-trial induction of LTM can also be achieved for aversive olfactory conditioning through inhibition of highwire (hiw)-encoded E3 ubiquitin ligase activity or activation of its targeted proteins in a cluster of neurons, localized within the α/β core region of the mushroom body. Moreover, the synaptic output of these neurons is critical within a limited posttraining interval for permitting consolidation of both aversive and appetitive LTM. CONCLUSIONS: We propose that these α/β core neurons serve as a "gate" to keep LTM from being formed, whereas any experience capable of "opening" the gate is given permit to be consolidated into LTM.

Item Type: Paper
Subjects: organism description > animal > insect > Drosophila
organism description > animal > insect
organism description > animal behavior > memory
organs, tissues, organelles, cell types and functions > tissues types and functions > mushroom body
organs, tissues, organelles, cell types and functions
organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:
Communities: CSHL labs > Zhong lab
Depositing User: Matt Covey
Date: 6 November 2012
Date Deposited: 30 Jan 2013 21:05
Last Modified: 30 Jan 2013 21:05
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26964

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