From cancer genomes to oncogenic drivers, tumour dependencies and therapeutic targets

Eifert, C., Powers, R. S. (June 2012) From cancer genomes to oncogenic drivers, tumour dependencies and therapeutic targets. Nat Rev Cancer, 12 (8). pp. 572-578. ISSN 1474-1768 (Electronic)1474-175X (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/22739505
DOI: 10.1038/nrc3299

Abstract

The analysis of human cancer by genome sequencing and various types of arrays has proved that many tumours harbour hundreds of genes that are mutated or substantially altered by copy number changes. But how many of these changes are meaningful? And how can we exploit these massive data sets to yield new targets for cancer treatment? In this Opinion article, we describe emerging approaches that aim to determine which altered genes are actually contributing to cancer, as well as their potential as therapeutic targets.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
diseases & disorders
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
therapies
therapies > cancer drugs - see diseases-cancer-drugs and therapies
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
CSHL Authors:
Communities: CSHL labs > Powers lab
Depositing User: Matt Covey
Date: 28 June 2012
Date Deposited: 31 Jan 2013 19:32
Last Modified: 31 Jan 2013 19:32
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26934

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